Chitosan osteoarthritis gene delivery

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August undefined, 2024

WebDec 1, 2016 · Efficacy of the combination of CM-cordycepin and HAMA hydrogel as a treatment for OA. Safranin-O staining of cartilage samples 4 weeks (A) and 8 weeks (B) after OA induction. WebDec 1, 2024 · Chitosan, a biopolymer of natural origin, has been explored for its variety of applications in biomedical research, medical diagnostic aids and material science. It is the second most abundant natural biopolymer after cellulose, and considered as an excellent excipient because of its non-toxic, stable, biodegradable properties.

Chondroprotective Effects of Hyaluronic Acid-Chitosan …

WebJun 1, 2024 · Chitosan is a natural polymer with inherent antibacterial activity and a hemostasis and wound healing acceleration capability, so it has been used in drug … WebConclusions: These results suggested that HA/CS-CrmA nanoparticles could attenuate cartilage destruction and protect against early OA by inhibiting synovial inflammation via … flixbus mailand bozen

Chitosan: A Promising Biopolymer For Sustainable Applications

WebApr 12, 2024 · Chitosan is a naturally occurring polysaccharide that is derived from chitin, a major component of the exoskeletons of crustaceans such as shrimp, crab, and lobster. It has been gaining attention in the field of biotechnology and biomedicine due to its unique properties and potential applications. Chitosan is a linear polysaccharide that consists of … WebNov 15, 2024 · (1) Background: Collagen is the main component of the connective tissue, playing an important role in the histological architecture and function of living organisms. Targeted therapy and improved imaging diagnosis can be obtained through collagen-binding nanoparticles that concentrate in the extracellular matrix. (2) Methods: We performed a … WebNov 28, 2011 · Gene therapy is a promising new treatment strategy for common joint-disorders such as osteoarthritis. The development of safe, effective, targeted non-viral … great gifts to buy

Novel nano-microspheres containing chitosan, hyaluronic acid, …

Direct chitosan-mediated gene delivery to the rabbit knee …

WebOsteoarthritis (OA) is a painful, degenerative and inflammatory disease that affects the entire synovial joints. Nowadays, no cure exists, and the pharmacological treatments … WebNov 28, 2011 · Gene therapy, which treats the causes of osteoarthritis by targeting specific pathological mechanisms, is attracting much attention as a promising new treatment … great gifts in a jar bookWebSep 14, 2024 · Chitosan is a derivation from chitin. Its favorable biological properties including biocompatible, biodegradable, and non-toxicity, make chitosan as a promising drug delivery carrier. In addition, chitosan is a water-soluble polymer which makes the process of preparation easier and milder. great gifts to get parents for christmas

"WebOct 16, 2024 · 2.2. CS-Based Modifications for Targeted Drug Delivery. When a drug enters the human body, various obstacles prevent it from reaching the disease site to elicit a specific therapeutic effect [].More importantly, drug often impart severe toxic side effects [].The current most effective strategy for solving the issues above mentioned is targeted … " - Chitosan osteoarthritis gene delivery

Chitosan osteoarthritis gene delivery

Application of chitosan with different molecular weights in …

WebJan 2, 2014 · The present study was designed to develop and evaluate the chitosan-graft-polyethylenimine (CP)/DNA nanoparticles as novel non-viral gene vectors for gene … WebFeb 23, 2024 · Keywords: Osteoarthritis, Gene therapy, Chitosan, Hyaluronic acid, Chondroitin sulfate, Growth and differentiation factor-5 (GDF-5) plasmid. 1. ... HA and CHS enabled the non-viral vector itself to have some therapeutic effects on OA, making it much more suitable for delivery of gene therapy treatments for OA.

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WebJan 28, 2024 · A The optical images of the gelation progress. The mixture of N-chitosan and ADH presented in the sol state at room temperature, and it experienced sol-gel … WebJan 1, 2024 · The chitosan-based gene delivery system has several characteristics such as insignificant cellular toxicity, high gene delivery ability, targeting of particular cells, …

WebJan 2, 2014 · Abstract. The development of safe and efficient gene carriers is the key to the clinical success of gene therapy. The present study was designed to develop and … WebDec 17, 2024 · To construct a novel non-viral vector loaded with growth and differentiation factor-5 (GDF-5) plasmid using chitosan, hyaluronic acid, and chondroitin sulfate for osteoarthritis (OA) gene therapy. Methods Nano-microspheres (NMPs) were prepared by mixing chitosan, hyaluronic acid, and chondroitin sulfate.

WebChitosan can act itself as a precursor or carrier for medical applications such as drug delivery, gene delivery, and wound healing. With the advancement in science … WebChitosan can act itself as a precursor or carrier for medical applications such as drug delivery, gene delivery, and wound healing. With the advancement in science technology, it was clearly observed that the amine groups present in chitosan are responsible for various properties such as antimicrobial activity, stability in a wide pH range ...

WebApr 11, 2024 · 1.3.1.Advantageous properties of chitosan as a biomaterial. Chitosan has a structure similar to that of glycine aminoglycan, which is widely distributed in connective tissue, giving chitosan good biocompatibility (Malafaya et al., 2007).Chitosan-based biomaterials do not cause cytotoxicity or genotoxicity and promote cell proliferation and …

WebJan 28, 2024 · Chitosan is considered as an ideal material for hydrogels for its biocompatibility, progressive degradability, non-toxic, biological activity, anti-inflammatory … great gifts to mailWebJan 1, 2024 · Thermoresponsive DDS, chitosan-modified MoS 2 (molybdenum disulfide), was shown to release a small molecule drug, dexamethasone (Dex) ... is most commonly employed osteoarthritis therapeutic for gene delivery; currently there are two ongoing trials for intra-articular delivery using an AAV (NCT02790723) and an HDAV … flixbus lyon toulouseWebAug 31, 2024 · Chitosan-based carriers have been recently considered for transporting hydrophobic agents such as chemotherapeutic compounds, therapeutic peptides, and nucleic acids ( e.g. DNA and siRNA) [67], [68]. great gifts to give momsWebAug 31, 2024 · Although gene delivery systems can be viral or non-viral, non-viral gene delivery materials are being specifically developed that could deliver the gene as a safer … great gifts to buy your boyfriendWebJun 6, 2024 · Chitosan is a linear copolymer composed by glucosamine and N -acteyl glucosamine units, via β- (1, 4) linkages, namely 2-amino-2-deoxy-β-d-glucan (Fig. 2 a). Chitosan is the product of the deacetylation reaction of chitin (2-acetamido-2 … flixbus mailand genuaWebApr 10, 2024 · Novel hyaluronic acid–chitosan nanoparticles as non-viral gene delivery vectors targeting osteoarthritis. International Journal of Pharmaceutics, 420 (2) (2011) ... Combining hyaluronic acid with chitosan enhances gene delivery. Journal of Nanomaterials (2014), 10.1155/2014/246347. 2014. Article 152. Google Scholar. flixbus mailand tübingenWebThere are two main approaches for gene delivery using viral and non-viral gene transfer systems for treating articular cartilage defects in OA, or following joint trauma. The first is … flixbus maastricht to frankfurt