Cisplatin atherosclerosis

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August undefined, 2024

WebJul 1, 2016 · Nephrotoxicity is a well documented adverse effect of cisplatin use, with a dose-dependent and irreversible reduction in renal function. 75, 76, 77 Possible mechanisms include endothelial and epithelial cell damage and dysfunction. 78 Patients treated with cisplatin-based chemotherapy have a high prevalence of microalbuminuria …

High dose ionizing radiation accelerates atherosclerotic plaque ...

WebOct 31, 2024 · It has been found that cisplatin may induce DNA damage and cancer cell death also by induction of oxidative stress, particularly the overproduction of mitochondrial reactive oxygen species (ROS) and by decreasing the pool of intracellular antioxidants, e.g. reduced glutathione (GSH). WebCisplatin is also used alone or in combination with other medications to treat bladder cancer that can not be treated with surgery or radiation therapy alone. Cisplatin is in a class of … cython安装conda

Cisplatin related cardiotoxicity – acute and chronic …

WebNational Center for Biotechnology Information WebIn addition, BANCR induced the proliferation of vascular smooth muscle cells by downregulating miR-34c methylation in atherosclerosis. 34 Here, we could not exclude the possibility that BANCR may attenuate the killing capacity of cisplatin on GC cells by regulating miRNAs. Further investigation is needed in our future study. WebTherefore, selective inhibition of CaMKIIγ in lesional macrophages holds great promise for the treatment of advanced atherosclerosis. We recently developed a siRNA NP platform that can selectively silence CaMKIIγ in macrophages, resulting in increased plaque stability. cython yolov5

Effects of Statins on Coronary Atherosclerotic Plaques: …

Gasdermin E deficiency attenuates acute kidney injury by …

WebFeb 1, 2024 · Cis-diamminedichloroplatinum (cisplatin) is an effective agent for treating solid tumors. However, its clinical use is limited by its serious toxic side effects; … WebDec 30, 2024 · However, cardiovascular toxicity is a major concern. In addition to acute endothelial toxicity and associated risk of arterial thrombosis, accelerated atherosclerosis may be the result of chemotherapy-associated latent cardio-metabolic dysfunction. A 45-year-old man began treatment with cisplatin-based chemotherapy for testicular cancer. cython安装linuxWebJul 1, 2024 · Atherosclerosis is a specific type of arteriosclerosis. Atherosclerosis is the buildup of fats, cholesterol and other substances in and on the artery walls. This buildup is called plaque. The plaque can … binfield print and design

"Web2 days ago · Radiation therapy (RT) significantly increased the incidence of coronary artery diseases, especially atherosclerosis. Endothelial dysfunction has been the major side effect of RT among tumor patients who received RT. However, the involvement between endothelial dysfunction and radiation-induced atherosclerosis (RIA) remains unclear. " - Cisplatin atherosclerosis

Cisplatin atherosclerosis

Inflammatory Cytokines and Atherosclerotic Plaque …

Web2 days ago · Radiation therapy (RT) significantly increased the incidence of coronary artery diseases, especially atherosclerosis. Endothelial dysfunction has been… WebAug 14, 2024 · Lipopolysaccharide (LPS) is an endotoxin that induces systemic inflammatory responses. Melittin, a main constituent of bee venom, exerts several biological activities such as antioxidant, anti-inflammatory, and antiapoptotic actions. However, whether melittin protects against endotoxin-induced AKI remains undetermined.

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WebAug 13, 2024 · Cisplatin was dissolved in dimethylformamide, and other chemicals were dissolved in dimethyl sulfoxide (DMSO) upon receipt. All chemicals were aliquoted and stored at −80 °C. Cell culture The... WebOct 10, 2024 · Late adverse vascular effects of platinum drugs have been attributed to platinum-related disruptions of vascular endothelial cells resulting in a …

WebAtherosclerosis is characterized by vascular obstruction from the deposits of plaque, resulting in reduced blood flow. Plaque rupture and the consequent thrombosis may lead to sudden blockage of the arteries and cause heart attack. WebSep 15, 2024 · DESCRIPTION. Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL …

WebDec 16, 2024 · Introduction: Cisplatin-based chemotherapeutic regimen (CBCR) is known for increasing risk of venous thromboembolic (TE) disease. We report a unique case of STEMI associated with CBCR which we believe was caused by coronary artery … WebOct 11, 2024 · Weakening of the heart muscle (cardiomyopathy) Heart rhythm problems (arrhythmia) Heart attack Stroke High blood pressure Blood clots Whether you're at risk …

WebDec 1, 2024 · Europe PMC is an archive of life sciences journal literature.

WebModern hypotheses introduce atherosclerosis as an inflammatory/lipid-based disease and NLRP3 inflammasome has been considered as a link between lipid metabolism and inflammation because crystalline cholesterol and oxidized low-density lipoprotein (oxLDL) (two abundant components in atherosclerotic plaques) activate NLRP3 inflammasome. cython yield not supported hereWebJun 27, 2014 · A 52-year-old executive was referred to our clinic for risk factor management after undergoing coronary computed tomography angiography (CTA) as part of an … binfield printers byfleetWebSep 1, 2024 · Cohort 1: Early effects of cisplatin-based chemotherapy Vascular function Participant characteristics are presented in Table 1. %FMD decreased 24 h after the first dose of cisplatin in the 10 patients managed with 3 to 4 cycles of BEP (16.7 ± 1.6 at baseline vs. 10.9 ± 0.9 at 24 h after cisplatin; p = 0.003) ( Figure 2 ). binfield rd maryville tnWebRecently, a genome-wide analysis of cisplatin-induced peripheral neuropathy in survivors of adult-onset cancer reported that genetically determined expression level of RPRD1B … binfield racketsWebMar 27, 2024 · Cisplatin (CisPt) is an alkylating drug that has been successfully used for decades to treat solid organ tumours such as lung, testis or ovarian cancers, resulting in an increased life expectancy for patients. binfield pubs restaurantsWebNational Center for Biotechnology Information cython yieldWebNov 5, 2024 · Since its introduction in the late 1970s, cisplatin-based chemotherapy (CBCT) has revolutionized the treatment of metastatic testicular cancer (TC) and … cython 打包 dll