Photoactivatable senolysis
Our main focus in designing this senolytic prodrug was ensuring the accurate delivery of the photosensitive drug to SnCs for precise and controllable yet complete senolysis with single-cell resolution. We then report a prodrug strategy to design a photosensitive senolytic agent activated by SA-β-gal, an enzyme … See more The fluorescence spectra and the absorption spectra of KSL0608-O and KSL0608-Se were evaluated. Escherichia coli β-gal (E. coli β-gal), as the SA-β-gal model … See more We then examined the ability of KSL0608-O and KSL0608-Se to convert oxygen into reactive oxygen species (ROS) after photoirradiation using a commercial ROS … See more Before cell imaging, the cytotoxicity of our compounds was evaluated, and both compounds exhibited low cytotoxicity (Supplementary Fig. 2). Human ovarian cancer … See more Senescent MRC-5 cells at passage 40 (P40) were co-incubated with KSL0608-O or KSL0608-Se and commercial staining dyes targeting different organelles. The NIR … See more WebReference: Photoactivatable senolysis with single-cell resolution delays aging. Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo. Citing article.
Photoactivatable senolysis
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WebSep 24, 2024 · Photoactivatable senolysis with single-cell resolution reverses aging: Organism: Mus musculus: Experiment type: Expression profiling by high throughput …
WebFeb 7, 2024 · 2024年2月2日,来自华东理工大学李剑教授和西北大学郭媛教授团队联合在NatureAging杂志发表题为“Photoactivatable senolysis with single-cell resolution delays aging”的文章,该文章整合了多种技术,将衰老相关 β-半乳糖苷酶 (SA-β-gal) 的酶底物与荧光标签相结合,并生成一种 ... WebA strategy to monitor and selectively eliminate senescent cells in mice during aging through controllable photodynamic therapy, which inhibited the age-related functional decline and countered age-induced losses in liver and renal function. Strategies that can selectively eliminate senescent cells (SnCs), namely senolytics, have been shown to promote healthy …
WebMar 2, 2024 · The development of plasmonic core-shell spiky nanorods (CSNRs) surface-modified with an anti- beta-2-microglobulin antibody and triphenylphosphonium (TPP) to target the mitochondria in senescent cells opens the way for the use of precisely regulated plasma nanostructures for immune adjuvant and photo-induced apoptosis for age-related … WebPhotoactivatable senolysis with single-cell resolution delays aging Donglei Shi, Wenwen Liu, Ying Gao, Xinming Li, Yunyuan Huang, Xiaokang Li, Tony James , Yuan Guo, Jian Li Centre …
WebFeb 3, 2024 · 接下来,研究团队在小鼠实验中测试了KSL0608-Se的治疗作用。. 他们发现,无论是自然衰老的小鼠,还是使用药物诱导衰老的小鼠,利用KSL0608-Se介导的光动力新技术策略治疗后,都有逆转衰老的效果。. 研究人员观察到,小鼠肝、肾等脏器积累的衰老细胞被 …
WebMay 7, 2015 · Icosahedral viruses were the first biological assemblies whose structures were determined at near-atomic resolution using cryo–electron microscopy (cryo-EM) combined with methods for image averaging (1–10 11–20), the 465-kD Escherichia coli). There is great potential for the use of cryo-EM methods in applications such as drug … smallest category 5 hurricaneWebNotably, the elimination of senescent cells (senolysis) was recently reported to improve normal and pathological changes associated with aging in mice (Baker et al., 2016;Xu et al., 2024) and the ... smallest catfish for aquariumsWebFeb 4, 2024 · Log in. Sign up smallest castle in scotlandWebPhotoactivatable senolysis with single-cell resolution delays aging ... SnCs with single-cell resolution and incorporation of a selenium atom to generate singlet oxygen and achieve precise ... song it\u0027s coming homeWebJan 15, 2024 · Inhibition of KGA-dependent glutaminolysis in aged mice eliminated senescent cells specifically and ameliorated age-associated organ dysfunction. Our … smallest cat bulldozerWebPhotoactivatable senolysis with single-cell resolution reverses aging. Expression profiling by high throughput sequencing; Mus musculus; 15: XLS; Wenwen Liu: Sep 24, 2024: GSE214034: Development of gene expression signatures for lnc-URIDS knock down rat dermal fibroblast. Expression profiling by array; Rattus norvegicus; 6: song it\u0027s closing timeWebPhotoactivatable senolysis with single-cell resolution reverses aging. Expression profiling by high throughput sequencing; Mus musculus; 15: XLS; Wenwen Liu song it\u0027s different for girls